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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling plays a role in various biological processes, including the metabolic processes of calcium and phosphorous and parathormone release. It also plays a role in cell proliferative processes, and the control of adaptive and innate immunity.
A T > C change in the promoter of the VDR variant (rs11568820) removes the binding site of the transcription factor Cdx2 just upstream of exon 1. This leads to an enlargement of the protein, which results in reduced transcriptional activity. The F allele of this variant is found at a high rate in Asians and Europeans and at a low frequency in Sub-Saharan Africa.
The findings of this study advance our understanding of the role that VDR gene polymorphisms could play in modulating the response to dietary supplementation with calcium calcitriol. The carriers of the TaqI and FF genotypes of the oldetowntimes.net/sims-4-debug-cheat-codes-get-the-most-out-of-your-game FokI polymorphisms have higher transcriptional activation and are associated with greater calcium absorption, a higher bone mineral density, and a reduced risk of breaking. Further research using an unbiased design is required to enhance our understanding of how these genetic variants influence vitamin D supplementation as well as its clinical significance.